Drug interactions
Dichlorphenamide + Fludrocortisone
Severity: Moderate
Dichlorphenamide and Fludrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs promote renal potassium loss, so used together they can cause clinically significant hypokalemia. This may lead to weakness and cardiac arrhythmias.
What this interaction means in plain words
Dichlorphenamide and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Fludrocortisone belongs to Endocrine.
Why it happens
Additive renal potassium wasting from mineralocorticoid activity and carbonic anhydrase inhibition.
What to do
Check serum potassium and bicarbonate at baseline and periodically. Replace potassium or adjust doses if hypokalemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fludrocortisone
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Fludrocortisone?
MediHelp rates the interaction as moderate. Dichlorphenamide and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs promote renal potassium loss, so used together they can cause clinically significant hypokalemia. This may lead to weakness and cardiac arrhythmias.
How serious is the interaction between Dichlorphenamide and Fludrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and bicarbonate at baseline and periodically. Replace potassium or adjust doses if hypokalemia develops.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
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