Drug interactions
Dichlorphenamide + Fluticasone-salmeterol
Severity: Moderate
Dichlorphenamide and Fluticasone-salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide, a carbonic anhydrase inhibitor, causes renal potassium wasting and metabolic acidosis, and salmeterol can further lower potassium. The combination may cause clinically significant hypokalemia and raise arrhythmia risk.
What this interaction means in plain words
Dichlorphenamide and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Fluticasone-salmeterol belongs to Respiratory.
Why it happens
Additive hypokalemia from renal potassium loss and beta-2 agonist-induced intracellular potassium shift.
What to do
Monitor serum potassium and bicarbonate periodically and supplement potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Fluticasone-salmeterol?
MediHelp rates the interaction as moderate. Dichlorphenamide and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide, a carbonic anhydrase inhibitor, causes renal potassium wasting and metabolic acidosis, and salmeterol can further lower potassium. The combination may cause clinically significant hypokalemia and raise arrhythmia risk.
How serious is the interaction between Dichlorphenamide and Fluticasone-salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and bicarbonate periodically and supplement potassium as needed.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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