Drug interactions
Ethiodized oil + Glipizide-metformin
Severity: Major
Ethiodized oil and Glipizide-metformin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethiodized oil is an iodinated contrast agent. When given intravascularly (for example lymphography or chemoembolization) it may be associated with renal impairment and thereby reduce metformin clearance, with risk of lactic acidosis.
What this interaction means in plain words
Ethiodized oil and Glipizide-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Contrast-associated kidney injury reduces renal elimination of metformin, leading to accumulation and lactic acidosis.
What to do
Hold metformin around intravascular administration in patients with eGFR below 30 or acute kidney injury. Restart after about 48 hours once renal function is confirmed stable.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Glipizide-metformin
Frequently asked questions
Can I take Ethiodized oil with Glipizide-metformin?
MediHelp rates the interaction as major. Ethiodized oil and Glipizide-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ethiodized oil is an iodinated contrast agent. When given intravascularly (for example lymphography or chemoembolization) it may be associated with renal impairment and thereby reduce metformin clearance, with risk of lactic acidosis.
How serious is the interaction between Ethiodized oil and Glipizide-metformin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold metformin around intravascular administration in patients with eGFR below 30 or acute kidney injury. Restart after about 48 hours once renal function is confirmed stable.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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