Drug interactions
Dichlorphenamide + Glyburide-metformin
Severity: Moderate
Dichlorphenamide and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide is a carbonic anhydrase inhibitor that causes hyperchloremic metabolic acidosis. Metformin can cause lactic acidosis, so the combination may raise the risk of serious acid-base disturbance, especially in patients with reduced renal function.
What this interaction means in plain words
Dichlorphenamide and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Glyburide-metformin belongs to Endocrine.
Why it happens
Additive acidosis: carbonic anhydrase inhibition causes renal bicarbonate loss while metformin impairs lactate clearance and increases lactate production.
What to do
Monitor serum bicarbonate and chloride at baseline and periodically, and assess renal function. Reduce or stop the metformin component or dichlorphenamide if persistent metabolic acidosis develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Glyburide-metformin?
MediHelp rates the interaction as moderate. Dichlorphenamide and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide is a carbonic anhydrase inhibitor that causes hyperchloremic metabolic acidosis. Metformin can cause lactic acidosis, so the combination may raise the risk of serious acid-base disturbance, especially in patients with reduced renal function.
How serious is the interaction between Dichlorphenamide and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum bicarbonate and chloride at baseline and periodically, and assess renal function. Reduce or stop the metformin component or dichlorphenamide if persistent metabolic acidosis develops.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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