Drug interactions
Dichlorphenamide + Hydrochlorothiazide-valsartan
Severity: Moderate
Dichlorphenamide and Hydrochlorothiazide-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide, a carbonic anhydrase inhibitor, and hydrochlorothiazide both promote urinary potassium loss. Together they can cause marked hypokalemia and metabolic acidosis, which may be clinically important.
What this interaction means in plain words
Dichlorphenamide and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Hydrochlorothiazide-valsartan belongs to Cardiovascular.
Why it happens
Additive renal potassium wasting from carbonic anhydrase inhibition and thiazide action at the distal tubule.
What to do
Monitor serum potassium and bicarbonate at baseline and periodically. Give potassium supplementation or modify therapy if levels fall.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as moderate. Dichlorphenamide and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide, a carbonic anhydrase inhibitor, and hydrochlorothiazide both promote urinary potassium loss. Together they can cause marked hypokalemia and metabolic acidosis, which may be clinically important.
How serious is the interaction between Dichlorphenamide and Hydrochlorothiazide-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and bicarbonate at baseline and periodically. Give potassium supplementation or modify therapy if levels fall.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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