Drug interactions
Dichlorphenamide + Ibuprofen
Severity: Moderate
Dichlorphenamide and Ibuprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide is a carbonic anhydrase inhibitor that can cause metabolic acidosis, and NSAIDs can contribute to acid-base disturbance and renal impairment. Combined use may worsen acidosis and electrolyte disturbance.
What this interaction means in plain words
Dichlorphenamide and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Ibuprofen belongs to Musculoskeletal.
Why it happens
Additive acid-base effects from carbonic anhydrase inhibition causing bicarbonate loss and NSAID-related reduction in renal function.
What to do
Monitor serum bicarbonate, potassium and renal function periodically during combined use. Reduce the dichlorphenamide dose or stop the NSAID if acidosis develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Ibuprofen?
MediHelp rates the interaction as moderate. Dichlorphenamide and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide is a carbonic anhydrase inhibitor that can cause metabolic acidosis, and NSAIDs can contribute to acid-base disturbance and renal impairment. Combined use may worsen acidosis and electrolyte disturbance.
How serious is the interaction between Dichlorphenamide and Ibuprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum bicarbonate, potassium and renal function periodically during combined use. Reduce the dichlorphenamide dose or stop the NSAID if acidosis develops.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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