Drug interactions
Dichlorphenamide + Ifosfamide
Severity: Moderate
Dichlorphenamide and Ifosfamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower serum potassium and cause metabolic acidosis, and ifosfamide can cause renal tubular injury. Together they may worsen electrolyte disturbance and acid-base imbalance.
What this interaction means in plain words
Dichlorphenamide and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Ifosfamide belongs to Oncology.
Why it happens
Additive hypokalemia and metabolic acidosis from carbonic anhydrase inhibition and ifosfamide-related proximal tubular toxicity.
What to do
Monitor serum bicarbonate, potassium and renal function, and correct abnormalities promptly. Consider stopping dichlorphenamide if significant acidosis develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Ifosfamide?
MediHelp rates the interaction as moderate. Dichlorphenamide and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lower serum potassium and cause metabolic acidosis, and ifosfamide can cause renal tubular injury. Together they may worsen electrolyte disturbance and acid-base imbalance.
How serious is the interaction between Dichlorphenamide and Ifosfamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum bicarbonate, potassium and renal function, and correct abnormalities promptly. Consider stopping dichlorphenamide if significant acidosis develops.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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