Drug interactions
Dichlorphenamide + Metformin-repaglinide
Severity: Moderate
Dichlorphenamide and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide is a carbonic anhydrase inhibitor that causes hyperchloremic metabolic acidosis, and metformin can cause lactic acidosis. Together they may increase the risk of serious acid-base disturbance.
What this interaction means in plain words
Dichlorphenamide and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Metformin-repaglinide belongs to Endocrine.
Why it happens
Additive pharmacodynamic effect on acid-base balance: carbonic anhydrase inhibition causes bicarbonate loss while metformin raises lactate.
What to do
Monitor serum bicarbonate and electrolytes at baseline and periodically, and assess renal function. Reduce the dose or stop one of the drugs if persistent metabolic acidosis develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Dichlorphenamide and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide is a carbonic anhydrase inhibitor that causes hyperchloremic metabolic acidosis, and metformin can cause lactic acidosis. Together they may increase the risk of serious acid-base disturbance.
How serious is the interaction between Dichlorphenamide and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum bicarbonate and electrolytes at baseline and periodically, and assess renal function. Reduce the dose or stop one of the drugs if persistent metabolic acidosis develops.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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