Drug interactions
Dichlorphenamide + Minocycline
Severity: Moderate
Dichlorphenamide and Minocycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide, a carbonic anhydrase inhibitor, causes metabolic acidosis. Tetracyclines such as minocycline have been associated with acidosis, so the effect may be additive, though this is not well established.
What this interaction means in plain words
Dichlorphenamide and Minocycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Minocycline belongs to Anti Bacterial.
Why it happens
Additive acid-base disturbance; carbonic anhydrase inhibition causes bicarbonate loss.
What to do
Monitor serum bicarbonate and acid-base status when starting or changing therapy. Reduce the dichlorphenamide dose or stop one agent if acidosis develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Minocycline
- Acitretin + Minocycline Contraindicated
- Isotretinoin + Minocycline Contraindicated
- Cholera vaccine + Minocycline Major
- Methoxyflurane + Minocycline Major
- Minocycline + Palovarotene Major
- Minocycline + Pexidartinib Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Minocycline?
MediHelp rates the interaction as moderate. Dichlorphenamide and Minocycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide, a carbonic anhydrase inhibitor, causes metabolic acidosis. Tetracyclines such as minocycline have been associated with acidosis, so the effect may be additive, though this is not well established.
How serious is the interaction between Dichlorphenamide and Minocycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum bicarbonate and acid-base status when starting or changing therapy. Reduce the dichlorphenamide dose or stop one agent if acidosis develops.
What other medicines interact with Minocycline?
MediHelp also lists interactions of Minocycline with, for example, Acitretin, Isotretinoin, Cholera vaccine. The full list is on the Minocycline page.
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