Drug interactions
Dichlorphenamide + Mitoxantrone
Severity: Moderate
Dichlorphenamide and Mitoxantrone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide commonly causes hypokalemia and metabolic acidosis. Mitoxantrone causes vomiting and diarrhea that can contribute to potassium loss, and hypokalemia raises cardiac arrhythmia risk in patients with anthracenedione cardiotoxicity.
What this interaction means in plain words
Dichlorphenamide and Mitoxantrone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Mitoxantrone belongs to Central Nervous System.
Why it happens
Additive potassium loss from carbonic anhydrase inhibition and gastrointestinal losses.
What to do
Monitor serum potassium and bicarbonate and replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mitoxantrone
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Mitoxantrone?
MediHelp rates the interaction as moderate. Dichlorphenamide and Mitoxantrone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide commonly causes hypokalemia and metabolic acidosis. Mitoxantrone causes vomiting and diarrhea that can contribute to potassium loss, and hypokalemia raises cardiac arrhythmia risk in patients with anthracenedione cardiotoxicity.
How serious is the interaction between Dichlorphenamide and Mitoxantrone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and bicarbonate and replace potassium as needed.
What other medicines interact with Mitoxantrone?
MediHelp also lists interactions of Mitoxantrone with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Mitoxantrone page.
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