Drug interactions
Dichlorphenamide + Nilotinib
Severity: Major
Dichlorphenamide and Nilotinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide causes renal potassium loss and metabolic acidosis, which can lead to hypokalemia. Nilotinib prolongs the QT interval and hypokalemia increases the risk of torsades de pointes, so the combination raises arrhythmia risk.
What this interaction means in plain words
Dichlorphenamide and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dichlorphenamide belongs to Miscellaneous; Nilotinib belongs to Oncology.
Why it happens
Additive pharmacodynamic effect: carbonic anhydrase inhibitor-induced hypokalemia potentiates nilotinib-related QT prolongation.
What to do
Check serum potassium and magnesium before starting and periodically during therapy, and correct deficits promptly. Obtain a baseline and follow-up ECG for QTc.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dichlorphenamide and Nilotinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Nilotinib?
MediHelp rates the interaction as major. Dichlorphenamide and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dichlorphenamide causes renal potassium loss and metabolic acidosis, which can lead to hypokalemia. Nilotinib prolongs the QT interval and hypokalemia increases the risk of torsades de pointes, so the combination raises arrhythmia risk.
How serious is the interaction between Dichlorphenamide and Nilotinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and magnesium before starting and periodically during therapy, and correct deficits promptly. Obtain a baseline and follow-up ECG for QTc.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
