Drug interactions
Dichlorphenamide + Oxcarbazepine
Severity: Moderate
Dichlorphenamide and Oxcarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower serum potassium, and oxcarbazepine can also cause hyponatremia. Combined use may increase the risk of hypokalemia and metabolic disturbance.
What this interaction means in plain words
Dichlorphenamide and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Oxcarbazepine belongs to Central Nervous System.
Why it happens
Additive potassium loss from carbonic anhydrase inhibition by dichlorphenamide, with oxcarbazepine's own electrolyte effects.
What to do
Monitor serum potassium, sodium and bicarbonate at baseline and periodically, and correct abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dichlorphenamide and Oxcarbazepine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Oxcarbazepine?
MediHelp rates the interaction as moderate. Dichlorphenamide and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lower serum potassium, and oxcarbazepine can also cause hyponatremia. Combined use may increase the risk of hypokalemia and metabolic disturbance.
How serious is the interaction between Dichlorphenamide and Oxcarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, sodium and bicarbonate at baseline and periodically, and correct abnormalities.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
