Drug interactions
Dichlorphenamide + Salmeterol
Severity: Moderate
Dichlorphenamide and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower serum potassium, and combined use may produce clinically relevant hypokalemia. This can predispose to arrhythmias and muscle weakness.
What this interaction means in plain words
Dichlorphenamide and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Salmeterol belongs to Respiratory.
Why it happens
Additive hypokalemia from beta-2 mediated intracellular potassium shift and carbonic anhydrase inhibitor renal potassium loss.
What to do
Monitor serum potassium at baseline and periodically, and supplement as needed. Be especially careful in patients with cardiac disease or on other potassium-lowering drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Salmeterol?
MediHelp rates the interaction as moderate. Dichlorphenamide and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lower serum potassium, and combined use may produce clinically relevant hypokalemia. This can predispose to arrhythmias and muscle weakness.
How serious is the interaction between Dichlorphenamide and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium at baseline and periodically, and supplement as needed. Be especially careful in patients with cardiac disease or on other potassium-lowering drugs.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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