Drug interactions
Dichlorphenamide + Spironolactone
Severity: Moderate
Dichlorphenamide and Spironolactone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can promote metabolic acidosis, and spironolactone may also cause hyperkalemia, which is aggravated by acidosis. Dichlorphenamide typically lowers potassium, so the net effect on potassium is variable. Acid-base and electrolyte disturbances may become clinically important.
What this interaction means in plain words
Dichlorphenamide and Spironolactone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Spironolactone belongs to Cardiovascular.
Why it happens
Additive acidifying effects: carbonic anhydrase inhibition causes bicarbonate loss while spironolactone reduces distal hydrogen and potassium secretion.
What to do
Monitor serum bicarbonate and potassium at baseline and periodically. Reduce the dose or stop one agent if significant acidosis develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dichlorphenamide and Spironolactone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Spironolactone?
MediHelp rates the interaction as moderate. Dichlorphenamide and Spironolactone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can promote metabolic acidosis, and spironolactone may also cause hyperkalemia, which is aggravated by acidosis. Dichlorphenamide typically lowers potassium, so the net effect on potassium is variable. Acid-base and electrolyte disturbances may become clinically important.
How serious is the interaction between Dichlorphenamide and Spironolactone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum bicarbonate and potassium at baseline and periodically. Reduce the dose or stop one agent if significant acidosis develops.
What other medicines interact with Spironolactone?
MediHelp also lists interactions of Spironolactone with, for example, Amiloride, Eplerenone, Triamterene. The full list is on the Spironolactone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
