Drug interactions
Dichlorphenamide + Sunitinib
Severity: Moderate
Dichlorphenamide and Sunitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide causes potassium loss and metabolic acidosis, which can predispose to arrhythmia in patients taking QT-prolonging sunitinib. The combined effect may be clinically relevant in patients with other risk factors.
What this interaction means in plain words
Dichlorphenamide and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Sunitinib belongs to Oncology.
Why it happens
Dichlorphenamide-induced hypokalemia adds to sunitinib's QT-prolonging potential.
What to do
Monitor potassium, magnesium and bicarbonate and replace as needed. Consider an ECG if other QT risk factors exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Sunitinib?
MediHelp rates the interaction as moderate. Dichlorphenamide and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide causes potassium loss and metabolic acidosis, which can predispose to arrhythmia in patients taking QT-prolonging sunitinib. The combined effect may be clinically relevant in patients with other risk factors.
How serious is the interaction between Dichlorphenamide and Sunitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium, magnesium and bicarbonate and replace as needed. Consider an ECG if other QT risk factors exist.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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