Drug interactions
Dichlorphenamide + Tobramycin
Severity: Moderate
Dichlorphenamide and Tobramycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide causes renal potassium and bicarbonate loss, and aminoglycosides can cause renal electrolyte wasting, so hypokalemia and hypomagnesemia may be more likely. Electrolyte disturbances may be clinically important in patients with arrhythmia risk.
What this interaction means in plain words
Dichlorphenamide and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Tobramycin belongs to Anti Bacterial.
Why it happens
Additive renal potassium wasting from carbonic anhydrase inhibition and aminoglycoside tubular effects.
What to do
Monitor serum potassium, magnesium and bicarbonate and replace deficits as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tobramycin
- Cidofovir + Tobramycin Contraindicated
- Adefovir + Tobramycin Major
- Amikacin + Tobramycin Major
- Amphotericin b deoxycholate + Tobramycin Major
- Amphotericin b + Tobramycin Major
- Atracurium + Tobramycin Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Tobramycin?
MediHelp rates the interaction as moderate. Dichlorphenamide and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide causes renal potassium and bicarbonate loss, and aminoglycosides can cause renal electrolyte wasting, so hypokalemia and hypomagnesemia may be more likely. Electrolyte disturbances may be clinically important in patients with arrhythmia risk.
How serious is the interaction between Dichlorphenamide and Tobramycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, magnesium and bicarbonate and replace deficits as needed.
What other medicines interact with Tobramycin?
MediHelp also lists interactions of Tobramycin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Tobramycin page.
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