Drug interactions
Dichlorphenamide + Triamterene
Severity: Moderate
Dichlorphenamide and Triamterene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide, a carbonic anhydrase inhibitor, causes metabolic acidosis and potassium loss, while triamterene can cause hyperkalemia and acidosis. Acidosis also shifts potassium out of cells, so the net effect on potassium is unpredictable and acid-base disturbance may worsen.
What this interaction means in plain words
Dichlorphenamide and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Triamterene belongs to Cardiovascular.
Why it happens
Additive acid-base effects from carbonic anhydrase inhibition and impaired renal hydrogen and potassium secretion by triamterene.
What to do
Monitor serum bicarbonate, potassium and renal function at baseline and regularly. Adjust or stop one drug if significant acidosis or potassium abnormality develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Triamterene?
MediHelp rates the interaction as moderate. Dichlorphenamide and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide, a carbonic anhydrase inhibitor, causes metabolic acidosis and potassium loss, while triamterene can cause hyperkalemia and acidosis. Acidosis also shifts potassium out of cells, so the net effect on potassium is unpredictable and acid-base disturbance may worsen.
How serious is the interaction between Dichlorphenamide and Triamterene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum bicarbonate, potassium and renal function at baseline and regularly. Adjust or stop one drug if significant acidosis or potassium abnormality develops.
What other medicines interact with Triamterene?
MediHelp also lists interactions of Triamterene with, for example, Amiloride, Eplerenone, Potassium citrate / citric acid. The full list is on the Triamterene page.
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