Drug interactions
Didanosine + Elvitegravir
Severity: Moderate
Didanosine and Elvitegravir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Didanosine must be taken on an empty stomach, whereas elvitegravir is given with food for adequate absorption. Simultaneous dosing therefore compromises one or both drugs.
What this interaction means in plain words
Didanosine and Elvitegravir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing food requirements; no direct pharmacokinetic interaction is established.
What to do
Take didanosine at least 1 hour before or 2 hours after elvitegravir with food.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Didanosine
- Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df Contraindicated
- Didanosine + Hydroxycarbamide Contraindicated
- Didanosine + Ribavirin Contraindicated
- Didanosine + Stavudine Contraindicated
- Allopurinol + Didanosine Major
- Atidarsagene autotemcel + Didanosine Major
Frequently asked questions
Can I take Didanosine with Elvitegravir?
MediHelp rates the interaction as moderate. Didanosine and Elvitegravir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Didanosine must be taken on an empty stomach, whereas elvitegravir is given with food for adequate absorption. Simultaneous dosing therefore compromises one or both drugs.
How serious is the interaction between Didanosine and Elvitegravir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take didanosine at least 1 hour before or 2 hours after elvitegravir with food.
What other medicines interact with Didanosine?
MediHelp also lists interactions of Didanosine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Hydroxycarbamide, Ribavirin. The full list is on the Didanosine page.
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