Drug reference
didanosine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Anti Virals (Antiretroviral)
Mechanism of action
Nucleoside Reverse Transcriptase Inhibitor (NRTI), Inhibits in vitro replication of HIV via chain termination & interference with HIV-RNA dependent DNA polymerase
Common side effects
- Increased uric acid
- Peripheral neuropathy
- Increased amylase
- Increased LFT
- Abdominal pain
- Diarrhea
Contraindications
- Hypersensitivity Coadministration with allopurinol (may increase didanosine toxicity) Coadministration with ribavirin (increases actrive metabolite dideoxyadenosine 5’-triphosphate levels, causing fatal hepatic failure, peripheral neuropathy, pancreatitis, and symptomatic hyperlactatemia/lact…
Known interactions (3)
- didanosine + ribavirin Contraindicated
- allopurinol + didanosine Major
- didanosine + febuxostat Major
Related conditions
Frequently asked questions
What drug class is didanosine?
didanosine belongs to: Anti Virals.
How does didanosine work?
Nucleoside Reverse Transcriptase Inhibitor (NRTI), Inhibits in vitro replication of HIV via chain termination & interference with HIV-RNA dependent DNA polymerase
What are the common side effects of didanosine?
Increased uric acid, Peripheral neuropathy, Increased amylase, Increased LFT, Abdominal pain, Diarrhea
Which drugs interact with didanosine?
ribavirin, allopurinol, febuxostat
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