Drug interactions
Didanosine + Ferrous fumarate
Severity: Minor
Didanosine and Ferrous fumarate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buffered formulations of didanosine raise gastric pH, which can reduce dissolution and absorption of oral iron salts. This may lessen the effectiveness of iron supplementation.
What this interaction means in plain words
Didanosine and Ferrous fumarate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Didanosine belongs to Anti Virals; Ferrous fumarate belongs to Miscellaneous.
Why it happens
Buffering agents in didanosine raise gastric pH, reducing solubility and absorption of non-heme iron.
What to do
Give iron at least 2 hours before the buffered didanosine formulation. Monitor hemoglobin and iron indices if anemia is being treated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Didanosine
- Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df Contraindicated
- Didanosine + Hydroxycarbamide Contraindicated
- Didanosine + Ribavirin Contraindicated
- Didanosine + Stavudine Contraindicated
- Allopurinol + Didanosine Major
- Atidarsagene autotemcel + Didanosine Major
Other interactions of Ferrous fumarate
Frequently asked questions
Can I take Didanosine with Ferrous fumarate?
MediHelp rates the interaction as minor. Didanosine and Ferrous fumarate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Buffered formulations of didanosine raise gastric pH, which can reduce dissolution and absorption of oral iron salts. This may lessen the effectiveness of iron supplementation.
How serious is the interaction between Didanosine and Ferrous fumarate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give iron at least 2 hours before the buffered didanosine formulation. Monitor hemoglobin and iron indices if anemia is being treated.
What other medicines interact with Didanosine?
MediHelp also lists interactions of Didanosine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Hydroxycarbamide, Ribavirin. The full list is on the Didanosine page.
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