Drug interactions
Didanosine + Indinavir
Severity: Moderate
Didanosine and Indinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir requires an acidic stomach for absorption, and buffered didanosine raises gastric pH. Concurrent dosing can lower indinavir levels and compromise viral suppression.
What this interaction means in plain words
Didanosine and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Buffer in didanosine raises gastric pH, reducing indinavir absorption.
What to do
Give indinavir at least 1 hour before buffered didanosine, both fasting.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Didanosine
- Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df Contraindicated
- Didanosine + Hydroxycarbamide Contraindicated
- Didanosine + Ribavirin Contraindicated
- Didanosine + Stavudine Contraindicated
- Allopurinol + Didanosine Major
- Atidarsagene autotemcel + Didanosine Major
Frequently asked questions
Can I take Didanosine with Indinavir?
MediHelp rates the interaction as moderate. Didanosine and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir requires an acidic stomach for absorption, and buffered didanosine raises gastric pH. Concurrent dosing can lower indinavir levels and compromise viral suppression.
How serious is the interaction between Didanosine and Indinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give indinavir at least 1 hour before buffered didanosine, both fasting.
What other medicines interact with Didanosine?
MediHelp also lists interactions of Didanosine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Hydroxycarbamide, Ribavirin. The full list is on the Didanosine page.
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