Drug interactions
Didanosine + Metronidazole
Severity: Moderate
Didanosine and Metronidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause peripheral neuropathy, and using them together may increase the likelihood or severity of nerve damage. Didanosine also carries a risk of pancreatitis, which adds to the need for vigilance.
What this interaction means in plain words
Didanosine and Metronidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Didanosine belongs to Anti Virals; Metronidazole belongs to Anti Parasitic.
Why it happens
Additive neurotoxicity from two drugs that independently damage peripheral nerves.
What to do
Avoid prolonged concurrent use where alternatives exist. Monitor for numbness, tingling or pain and stop one agent if neuropathy develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Didanosine
- Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df Contraindicated
- Didanosine + Hydroxycarbamide Contraindicated
- Didanosine + Ribavirin Contraindicated
- Didanosine + Stavudine Contraindicated
- Allopurinol + Didanosine Major
- Atidarsagene autotemcel + Didanosine Major
Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Frequently asked questions
Can I take Didanosine with Metronidazole?
MediHelp rates the interaction as moderate. Didanosine and Metronidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause peripheral neuropathy, and using them together may increase the likelihood or severity of nerve damage. Didanosine also carries a risk of pancreatitis, which adds to the need for vigilance.
How serious is the interaction between Didanosine and Metronidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged concurrent use where alternatives exist. Monitor for numbness, tingling or pain and stop one agent if neuropathy develops.
What other medicines interact with Didanosine?
MediHelp also lists interactions of Didanosine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Hydroxycarbamide, Ribavirin. The full list is on the Didanosine page.
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