Drug interactions
Dienogest / estradiol valerate + Glipizide-metformin
Severity: Moderate
Dienogest / estradiol valerate and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hormonal contraceptive combinations can slightly worsen glucose tolerance and may weaken the effect of antidiabetic drugs. The effect is generally small with modern low-dose products.
What this interaction means in plain words
Dienogest / estradiol valerate and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Estrogen and progestin components can induce insulin resistance and alter hepatic carbohydrate metabolism, opposing glucose-lowering drugs.
What to do
Monitor glucose and HbA1c after starting or stopping the hormonal product and adjust antidiabetic therapy if control changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dienogest / estradiol valerate and Glipizide-metformin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glipizide-metformin
Frequently asked questions
Can I take Dienogest / estradiol valerate with Glipizide-metformin?
MediHelp rates the interaction as moderate. Dienogest / estradiol valerate and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hormonal contraceptive combinations can slightly worsen glucose tolerance and may weaken the effect of antidiabetic drugs. The effect is generally small with modern low-dose products.
How serious is the interaction between Dienogest / estradiol valerate and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c after starting or stopping the hormonal product and adjust antidiabetic therapy if control changes.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
