Drug interactions
Dienogest / estradiol valerate + Insulin degludec
Severity: Moderate
Dienogest / estradiol valerate and Insulin degludec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combined estrogen and progestin products can impair glucose tolerance and reduce insulin sensitivity. Insulin degludec may be less effective, and glucose levels can rise.
What this interaction means in plain words
Dienogest / estradiol valerate and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism from hormone-related reduction in insulin sensitivity.
What to do
Monitor glucose more often after starting or changing the hormonal product. Adjust the insulin degludec dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dienogest / estradiol valerate and Insulin degludec, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Insulin degludec
Frequently asked questions
Can I take Dienogest / estradiol valerate with Insulin degludec?
MediHelp rates the interaction as moderate. Dienogest / estradiol valerate and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combined estrogen and progestin products can impair glucose tolerance and reduce insulin sensitivity. Insulin degludec may be less effective, and glucose levels can rise.
How serious is the interaction between Dienogest / estradiol valerate and Insulin degludec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose more often after starting or changing the hormonal product. Adjust the insulin degludec dose if needed.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
