Drug interactions
Dienogest / estradiol valerate + Insulin glargine-lixisenatide
Severity: Minor
Dienogest / estradiol valerate and Insulin glargine-lixisenatide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lixisenatide delays gastric emptying and may reduce or delay absorption of oral drugs such as hormonal contraceptives. Reduced hormone exposure could in theory lower contraceptive reliability, although the effect is not well quantified.
What this interaction means in plain words
Dienogest / estradiol valerate and Insulin glargine-lixisenatide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Delayed gastric emptying from lixisenatide slows absorption of oral steroid hormones.
What to do
Take the oral contraceptive at least one hour before lixisenatide, or about eleven hours after it, as labeling suggests.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Frequently asked questions
Can I take Dienogest / estradiol valerate with Insulin glargine-lixisenatide?
MediHelp rates the interaction as minor. Dienogest / estradiol valerate and Insulin glargine-lixisenatide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lixisenatide delays gastric emptying and may reduce or delay absorption of oral drugs such as hormonal contraceptives. Reduced hormone exposure could in theory lower contraceptive reliability, although the effect is not well quantified.
How serious is the interaction between Dienogest / estradiol valerate and Insulin glargine-lixisenatide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take the oral contraceptive at least one hour before lixisenatide, or about eleven hours after it, as labeling suggests.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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