Drug interactions
Dienogest / estradiol valerate + Ofloxacin
Severity: Minor
Dienogest / estradiol valerate and Ofloxacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotics are theorized to lower hormone levels by disrupting gut flora and enterohepatic recycling of estrogen. With fluoroquinolones such as ofloxacin, no clinically important reduction in contraceptive efficacy has been shown.
What this interaction means in plain words
Dienogest / estradiol valerate and Ofloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical reduction in enterohepatic recirculation of estrogen through altered gut flora; not established for fluoroquinolones.
What to do
No routine change is needed. Counsel the patient to report breakthrough bleeding, and consider backup contraception if vomiting or severe diarrhea occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Dienogest / estradiol valerate with Ofloxacin?
MediHelp rates the interaction as minor. Dienogest / estradiol valerate and Ofloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antibiotics are theorized to lower hormone levels by disrupting gut flora and enterohepatic recycling of estrogen. With fluoroquinolones such as ofloxacin, no clinically important reduction in contraceptive efficacy has been shown.
How serious is the interaction between Dienogest / estradiol valerate and Ofloxacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Counsel the patient to report breakthrough bleeding, and consider backup contraception if vomiting or severe diarrhea occurs.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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