Drug interactions
Dienogest / estradiol valerate + Pioglitazone
Severity: Minor
Dienogest / estradiol valerate and Pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pioglitazone has been associated with a modest reduction in ethinylestradiol and norethindrone exposure, and may lower exposure to other contraceptive steroids. The effect is thought to be small, but contraceptive reliability could theoretically be reduced.
What this interaction means in plain words
Dienogest / estradiol valerate and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak CYP3A4 induction by pioglitazone increasing metabolism of the hormones.
What to do
Counsel patients to report breakthrough bleeding. Consider additional contraception if contraceptive efficacy is a particular concern.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pioglitazone
Frequently asked questions
Can I take Dienogest / estradiol valerate with Pioglitazone?
MediHelp rates the interaction as minor. Dienogest / estradiol valerate and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pioglitazone has been associated with a modest reduction in ethinylestradiol and norethindrone exposure, and may lower exposure to other contraceptive steroids. The effect is thought to be small, but contraceptive reliability could theoretically be reduced.
How serious is the interaction between Dienogest / estradiol valerate and Pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report breakthrough bleeding. Consider additional contraception if contraceptive efficacy is a particular concern.
What other medicines interact with Pioglitazone?
MediHelp also lists interactions of Pioglitazone with, for example, Insulin aspart-insulin aspart protamine, Insulin aspart, Insulin degludec-insulin aspart. The full list is on the Pioglitazone page.
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