Drug interactions
Diethylpropion + Fluticasone-salmeterol
Severity: Moderate
Diethylpropion and Fluticasone-salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diethylpropion is a sympathomimetic appetite suppressant that can raise heart rate and blood pressure. Salmeterol adds beta-adrenergic cardiac stimulation, so palpitations, tachycardia and hypertension may be more pronounced, especially in patients with cardiovascular disease.
What this interaction means in plain words
Diethylpropion and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sympathomimetic cardiovascular stimulation.
What to do
Monitor heart rate and blood pressure and avoid the combination in patients with uncontrolled hypertension or arrhythmia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Frequently asked questions
Can I take Diethylpropion with Fluticasone-salmeterol?
MediHelp rates the interaction as moderate. Diethylpropion and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diethylpropion is a sympathomimetic appetite suppressant that can raise heart rate and blood pressure. Salmeterol adds beta-adrenergic cardiac stimulation, so palpitations, tachycardia and hypertension may be more pronounced, especially in patients with cardiovascular disease.
How serious is the interaction between Diethylpropion and Fluticasone-salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure and avoid the combination in patients with uncontrolled hypertension or arrhythmia.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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