Drug interactions
Diethylpropion + Glipizide-metformin
Severity: Moderate
Diethylpropion and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diethylpropion is a sympathomimetic appetite suppressant that may change insulin and oral antidiabetic requirements. Weight loss and reduced intake may increase hypoglycemia risk with glipizide, while sympathomimetic effects may raise glucose.
What this interaction means in plain words
Diethylpropion and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Sympathomimetic stimulation and altered food intake change glucose levels, producing unpredictable pharmacodynamic effects on antidiabetic therapy.
What to do
Monitor glucose closely when starting or stopping diethylpropion and reduce the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Frequently asked questions
Can I take Diethylpropion with Glipizide-metformin?
MediHelp rates the interaction as moderate. Diethylpropion and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diethylpropion is a sympathomimetic appetite suppressant that may change insulin and oral antidiabetic requirements. Weight loss and reduced intake may increase hypoglycemia risk with glipizide, while sympathomimetic effects may raise glucose.
How serious is the interaction between Diethylpropion and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose closely when starting or stopping diethylpropion and reduce the glipizide dose if hypoglycemia occurs.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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