Drug interactions
Diethylpropion + Hydralazine
Severity: Moderate
Diethylpropion and Hydralazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diethylpropion is a sympathomimetic appetite suppressant that can increase blood pressure and heart rate. This may counteract hydralazine and worsen reflex tachycardia.
What this interaction means in plain words
Diethylpropion and Hydralazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Sympathomimetic release of catecholamines causes vasoconstriction and increased cardiac stimulation, opposing hydralazine.
What to do
Monitor blood pressure and heart rate regularly. Adjust antihypertensive therapy or stop the anorectic if blood pressure rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Frequently asked questions
Can I take Diethylpropion with Hydralazine?
MediHelp rates the interaction as moderate. Diethylpropion and Hydralazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diethylpropion is a sympathomimetic appetite suppressant that can increase blood pressure and heart rate. This may counteract hydralazine and worsen reflex tachycardia.
How serious is the interaction between Diethylpropion and Hydralazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate regularly. Adjust antihypertensive therapy or stop the anorectic if blood pressure rises.
What other medicines interact with Hydralazine?
MediHelp also lists interactions of Hydralazine with, for example, Amifostine, Aceclofenac, Acemetacin. The full list is on the Hydralazine page.
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