Drug interactions
Diethylpropion + Isocarboxazid
Severity: Contraindicated
Diethylpropion and Isocarboxazid: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diethylpropion is a sympathomimetic anorectic, and together with an MAOI it can cause hypertensive crisis. It is contraindicated during and shortly after MAOI therapy.
What this interaction means in plain words
Diethylpropion and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
MAO inhibition combined with sympathomimetic catecholamine release causes additive pressor effects.
What to do
Avoid the combination and wait at least 14 days after stopping the MAOI. Use non-stimulant approaches to weight management.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Diethylpropion with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Diethylpropion and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Diethylpropion is a sympathomimetic anorectic, and together with an MAOI it can cause hypertensive crisis. It is contraindicated during and shortly after MAOI therapy.
How serious is the interaction between Diethylpropion and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and wait at least 14 days after stopping the MAOI. Use non-stimulant approaches to weight management.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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