Drug interactions
Diethylpropion + Lorazepam
Severity: Minor
Diethylpropion and Lorazepam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorazepam is sedating whereas diethylpropion is a stimulant anorectic, so their effects may partly oppose each other. The net effect is unpredictable, and stimulant effects may mask sedation without removing benzodiazepine impairment.
What this interaction means in plain words
Diethylpropion and Lorazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing pharmacodynamic effects: GABAergic CNS depression versus sympathomimetic CNS stimulation; no established pharmacokinetic interaction.
What to do
No dose change is usually needed; monitor for altered alertness and anxiety or agitation, and do not rely on the stimulant to offset sedation when driving.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lorazepam
Frequently asked questions
Can I take Diethylpropion with Lorazepam?
MediHelp rates the interaction as minor. Diethylpropion and Lorazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lorazepam is sedating whereas diethylpropion is a stimulant anorectic, so their effects may partly oppose each other. The net effect is unpredictable, and stimulant effects may mask sedation without removing benzodiazepine impairment.
How serious is the interaction between Diethylpropion and Lorazepam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for altered alertness and anxiety or agitation, and do not rely on the stimulant to offset sedation when driving.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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