Drug interactions
Diethylpropion + Methyldopa
Severity: Moderate
Diethylpropion and Methyldopa: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diethylpropion is a sympathomimetic anorectic that can raise blood pressure and heart rate. It may counteract the blood pressure lowering effect of methyldopa, and labeling advises that it can interfere with antihypertensive therapy.
What this interaction means in plain words
Diethylpropion and Methyldopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism between sympathomimetic pressor activity and methyldopa's central sympatholytic effect.
What to do
Monitor blood pressure regularly while the two are used together. Adjust the antihypertensive regimen if control worsens, or avoid the anorectic in uncontrolled hypertension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methyldopa
- Methyldopa + Tranylcypromine Contraindicated
- Iobenguane i + Methyldopa Major
- Lofexidine + Methyldopa Major
- Methyldopa + Pexidartinib Major
- Methyldopa + Pretomanid Major
- Methyldopa + Thioridazine Major
Frequently asked questions
Can I take Diethylpropion with Methyldopa?
MediHelp rates the interaction as moderate. Diethylpropion and Methyldopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diethylpropion is a sympathomimetic anorectic that can raise blood pressure and heart rate. It may counteract the blood pressure lowering effect of methyldopa, and labeling advises that it can interfere with antihypertensive therapy.
How serious is the interaction between Diethylpropion and Methyldopa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure regularly while the two are used together. Adjust the antihypertensive regimen if control worsens, or avoid the anorectic in uncontrolled hypertension.
What other medicines interact with Methyldopa?
MediHelp also lists interactions of Methyldopa with, for example, Tranylcypromine, Iobenguane i, Lofexidine. The full list is on the Methyldopa page.
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