Drug interactions
Diethylpropion + Morphine
Severity: Minor
Diethylpropion and Morphine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diethylpropion is a sympathomimetic stimulant appetite suppressant, while morphine is a sedative. Stimulation may mask opioid sedation, and no clinically important interaction is well documented.
What this interaction means in plain words
Diethylpropion and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing pharmacodynamic CNS effects; no established pharmacokinetic mechanism.
What to do
Monitor blood pressure, heart rate and respiratory status when both are used. Titrate morphine to pain relief rather than to alertness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Frequently asked questions
Can I take Diethylpropion with Morphine?
MediHelp rates the interaction as minor. Diethylpropion and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Diethylpropion is a sympathomimetic stimulant appetite suppressant, while morphine is a sedative. Stimulation may mask opioid sedation, and no clinically important interaction is well documented.
How serious is the interaction between Diethylpropion and Morphine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and respiratory status when both are used. Titrate morphine to pain relief rather than to alertness.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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