Drug interactions
Diethylpropion + Rasagiline
Severity: Contraindicated
Diethylpropion and Rasagiline: contraindicated interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diethylpropion is a sympathomimetic amine, and combining it with an MAO inhibitor can precipitate a hypertensive crisis. The label advises against using it with or soon after MAO inhibitors.
What this interaction means in plain words
Diethylpropion and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
MAO inhibition prevents breakdown of catecholamines and increases the release and effect of sympathomimetic amines.
What to do
Avoid the combination. Choose a non-sympathomimetic approach to weight management.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Diethylpropion with Rasagiline?
MediHelp rates the interaction as contraindicated. Diethylpropion and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Diethylpropion is a sympathomimetic amine, and combining it with an MAO inhibitor can precipitate a hypertensive crisis. The label advises against using it with or soon after MAO inhibitors.
How serious is the interaction between Diethylpropion and Rasagiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Choose a non-sympathomimetic approach to weight management.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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