Drug interactions
Diethylpropion + Salmeterol
Severity: Moderate
Diethylpropion and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diethylpropion is a sympathomimetic anorectic that can raise heart rate and blood pressure. With salmeterol the cardiovascular stimulation may be additive.
What this interaction means in plain words
Diethylpropion and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sympathomimetic effects through beta-adrenergic stimulation and catecholamine release.
What to do
Monitor blood pressure, heart rate and arrhythmia symptoms. Avoid in patients with uncontrolled hypertension or significant heart disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Frequently asked questions
Can I take Diethylpropion with Salmeterol?
MediHelp rates the interaction as moderate. Diethylpropion and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diethylpropion is a sympathomimetic anorectic that can raise heart rate and blood pressure. With salmeterol the cardiovascular stimulation may be additive.
How serious is the interaction between Diethylpropion and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and arrhythmia symptoms. Avoid in patients with uncontrolled hypertension or significant heart disease.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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