Drug interactions
Difenoxin + Lofexidine
Severity: Moderate
Difenoxin and Lofexidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difenoxin is an opioid-related antidiarrheal that can cause CNS depression, adding to lofexidine's sedation and hypotension. Drowsiness and dizziness may be increased.
What this interaction means in plain words
Difenoxin and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Difenoxin belongs to Gastrointestinal Tract; Lofexidine belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Monitor sedation and blood pressure, and advise patients to avoid driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Other interactions of Difenoxin
Frequently asked questions
Can I take Difenoxin with Lofexidine?
MediHelp rates the interaction as moderate. Difenoxin and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difenoxin is an opioid-related antidiarrheal that can cause CNS depression, adding to lofexidine's sedation and hypotension. Drowsiness and dizziness may be increased.
How serious is the interaction between Difenoxin and Lofexidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure, and advise patients to avoid driving until the response is known.
What other medicines interact with Lofexidine?
MediHelp also lists interactions of Lofexidine with, for example, Adagrasib, Alfuzosin, Amiodarone. The full list is on the Lofexidine page.
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