Drug interactions
Difenoxin + Lorazepam
Severity: Moderate
Difenoxin and Lorazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difenoxin is an opioid antidiarrheal and, in higher exposures, can cause CNS and respiratory depression. With lorazepam the sedative effects are additive.
What this interaction means in plain words
Difenoxin and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Difenoxin belongs to Gastrointestinal Tract; Lorazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression via opioid receptor agonism and GABA-A potentiation.
What to do
Use recommended antidiarrheal doses only and monitor for sedation and slowed breathing; avoid alcohol and other depressants.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Other interactions of Difenoxin
Frequently asked questions
Can I take Difenoxin with Lorazepam?
MediHelp rates the interaction as moderate. Difenoxin and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difenoxin is an opioid antidiarrheal and, in higher exposures, can cause CNS and respiratory depression. With lorazepam the sedative effects are additive.
How serious is the interaction between Difenoxin and Lorazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use recommended antidiarrheal doses only and monitor for sedation and slowed breathing; avoid alcohol and other depressants.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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