Drug interactions
Dihydroergotamine intranasal + Morphine
Severity: Minor
Dihydroergotamine intranasal and Morphine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have some serotonergic activity, so additive effects are theoretically possible. The risk with morphine is low, and intranasal dihydroergotamine is used intermittently.
What this interaction means in plain words
Dihydroergotamine intranasal and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive serotonergic effects; morphine has weak serotonergic activity and dihydroergotamine is a 5-HT receptor agonist.
What to do
Monitor for signs of serotonin toxicity such as agitation, clonus, tremor and hyperthermia. No routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Frequently asked questions
Can I take Dihydroergotamine intranasal with Morphine?
MediHelp rates the interaction as minor. Dihydroergotamine intranasal and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs have some serotonergic activity, so additive effects are theoretically possible. The risk with morphine is low, and intranasal dihydroergotamine is used intermittently.
How serious is the interaction between Dihydroergotamine intranasal and Morphine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin toxicity such as agitation, clonus, tremor and hyperthermia. No routine dose change is needed.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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