Drug interactions
Dihydroergotamine intranasal + Paroxetine
Severity: Moderate
Dihydroergotamine intranasal and Paroxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents enhance serotonergic activity, so combining them may raise the risk of serotonin syndrome. Paroxetine is also a CYP2D6 inhibitor with some effect on ergot handling, and the clinical evidence for the combination is limited to isolated reports.
What this interaction means in plain words
Dihydroergotamine intranasal and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects from SSRI reuptake inhibition and ergot 5-HT1 receptor agonism.
What to do
Monitor for agitation, tremor, hyperreflexia, diaphoresis and hyperthermia after starting or increasing either drug. Stop both and treat supportively if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Dihydroergotamine intranasal with Paroxetine?
MediHelp rates the interaction as moderate. Dihydroergotamine intranasal and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents enhance serotonergic activity, so combining them may raise the risk of serotonin syndrome. Paroxetine is also a CYP2D6 inhibitor with some effect on ergot handling, and the clinical evidence for the combination is limited to isolated reports.
How serious is the interaction between Dihydroergotamine intranasal and Paroxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperreflexia, diaphoresis and hyperthermia after starting or increasing either drug. Stop both and treat supportively if serotonin syndrome is suspected.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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