Drug interactions
Dihydroergotamine intranasal + Rasagiline
Severity: Moderate
Dihydroergotamine intranasal and Rasagiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intranasal dihydroergotamine has serotonergic and vasoconstrictive activity, and combining it with an MAO inhibitor may increase the risk of serotonin syndrome and hypertension.
What this interaction means in plain words
Dihydroergotamine intranasal and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic and vasoactive effects with MAO inhibition.
What to do
Monitor for serotonin toxicity and blood pressure changes. Choose another migraine therapy if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Dihydroergotamine intranasal with Rasagiline?
MediHelp rates the interaction as moderate. Dihydroergotamine intranasal and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intranasal dihydroergotamine has serotonergic and vasoconstrictive activity, and combining it with an MAO inhibitor may increase the risk of serotonin syndrome and hypertension.
How serious is the interaction between Dihydroergotamine intranasal and Rasagiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin toxicity and blood pressure changes. Choose another migraine therapy if symptoms develop.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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