Drug interactions
Diltiazem + Docetaxel
Severity: Moderate
Diltiazem and Docetaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem may increase docetaxel exposure, raising the risk of neutropenia, mucositis and fluid retention.
What this interaction means in plain words
Diltiazem and Docetaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diltiazem belongs to Cardiovascular; Docetaxel belongs to Oncology.
Why it happens
Diltiazem inhibits CYP3A4, the principal metabolic pathway for docetaxel.
What to do
Monitor blood counts and toxicity, and consider docetaxel dose reduction or an alternative to diltiazem.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Diltiazem and Docetaxel, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Docetaxel
Frequently asked questions
Can I take Diltiazem with Docetaxel?
MediHelp rates the interaction as moderate. Diltiazem and Docetaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem may increase docetaxel exposure, raising the risk of neutropenia, mucositis and fluid retention.
How serious is the interaction between Diltiazem and Docetaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and toxicity, and consider docetaxel dose reduction or an alternative to diltiazem.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
