Drug interactions
Diltiazem + Empagliflozin-metformin
Severity: Minor
Diltiazem and Empagliflozin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium channel blockers such as diltiazem may modestly worsen glucose tolerance in some patients. Diltiazem may also affect metformin exposure through transporter inhibition, although the effect is small.
What this interaction means in plain words
Diltiazem and Empagliflozin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diltiazem belongs to Cardiovascular; Empagliflozin-metformin belongs to Endocrine.
Why it happens
Possible reduced insulin release and effects on cation transporters; the mechanism is not firmly established.
What to do
Monitor blood glucose after starting or stopping diltiazem and adjust antidiabetic therapy if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Empagliflozin-metformin
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Diltiazem with Empagliflozin-metformin?
MediHelp rates the interaction as minor. Diltiazem and Empagliflozin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium channel blockers such as diltiazem may modestly worsen glucose tolerance in some patients. Diltiazem may also affect metformin exposure through transporter inhibition, although the effect is small.
How serious is the interaction between Diltiazem and Empagliflozin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or stopping diltiazem and adjust antidiabetic therapy if control changes.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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