Drug interactions
Diltiazem + Erdafitinib
Severity: Minor
Diltiazem and Erdafitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib may inhibit P-glycoprotein and modestly raise levels of P-gp substrates. Diltiazem is a P-gp substrate but not narrow therapeutic index, so the impact is likely limited.
What this interaction means in plain words
Diltiazem and Erdafitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diltiazem belongs to Cardiovascular; Erdafitinib belongs to Oncology.
Why it happens
Erdafitinib inhibits intestinal P-glycoprotein efflux, potentially increasing diltiazem absorption.
What to do
No routine change is needed; monitor heart rate and blood pressure when starting erdafitinib. Separating doses by 6 hours may be considered.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Erdafitinib
Frequently asked questions
Can I take Diltiazem with Erdafitinib?
MediHelp rates the interaction as minor. Diltiazem and Erdafitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erdafitinib may inhibit P-glycoprotein and modestly raise levels of P-gp substrates. Diltiazem is a P-gp substrate but not narrow therapeutic index, so the impact is likely limited.
How serious is the interaction between Diltiazem and Erdafitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor heart rate and blood pressure when starting erdafitinib. Separating doses by 6 hours may be considered.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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