Drug interactions
Diltiazem + Etrasimod
Severity: Moderate
Diltiazem and Etrasimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod can cause a transient fall in heart rate and AV conduction delay when started. Diltiazem also slows sinus rate and AV nodal conduction, so the bradycardic and conduction effects may be additive. The effect of adding a rate-lowering calcium channel blocker is not well characterized.
What this interaction means in plain words
Diltiazem and Etrasimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diltiazem belongs to Cardiovascular; Etrasimod belongs to Gastrointestinal Tract.
Why it happens
Additive pharmacodynamic depression of sinus node function and AV conduction.
What to do
Review ECG and baseline heart rate before starting etrasimod in patients taking diltiazem, and monitor heart rate and PR interval after initiation. Seek cardiology advice if there is pre-existing conduction disease or bradycardia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Diltiazem with Etrasimod?
MediHelp rates the interaction as moderate. Diltiazem and Etrasimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etrasimod can cause a transient fall in heart rate and AV conduction delay when started. Diltiazem also slows sinus rate and AV nodal conduction, so the bradycardic and conduction effects may be additive. The effect of adding a rate-lowering calcium channel blocker is not well characterized.
How serious is the interaction between Diltiazem and Etrasimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review ECG and baseline heart rate before starting etrasimod in patients taking diltiazem, and monitor heart rate and PR interval after initiation. Seek cardiology advice if there is pre-existing conduction disease or bradycardia.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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