Drug interactions
Diltiazem + Filgotinib
Severity: Minor
Diltiazem and Filgotinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem inhibits CES2 in vitro, which could theoretically alter filgotinib metabolism. No clinically significant effect has been shown.
What this interaction means in plain words
Diltiazem and Filgotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diltiazem belongs to Cardiovascular; Filgotinib belongs to Miscellaneous.
Why it happens
Possible in vitro inhibition of CES2-mediated filgotinib metabolism.
What to do
No dose adjustment is needed; monitor clinical response to filgotinib as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Filgotinib
- Carvedilol + Filgotinib Minor
- Fenofibrate + Filgotinib Minor
- Filgotinib + Simvastatin Minor
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Diltiazem with Filgotinib?
MediHelp rates the interaction as minor. Diltiazem and Filgotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Diltiazem inhibits CES2 in vitro, which could theoretically alter filgotinib metabolism. No clinically significant effect has been shown.
How serious is the interaction between Diltiazem and Filgotinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor clinical response to filgotinib as usual.
What other medicines interact with Filgotinib?
MediHelp also lists interactions of Filgotinib with, for example, Carvedilol, Fenofibrate, Simvastatin. The full list is on the Filgotinib page.
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