Drug interactions
Fenofibrate + Filgotinib
Severity: Minor
Fenofibrate and Filgotinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenofibrate inhibits CES2 in vitro, and CES2 converts filgotinib to its active metabolite. The clinical relevance is unknown and no meaningful effect has been demonstrated.
What this interaction means in plain words
Fenofibrate and Filgotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fenofibrate belongs to Cardiovascular; Filgotinib belongs to Miscellaneous.
Why it happens
Possible in vitro inhibition of CES2-mediated filgotinib metabolism.
What to do
No dose adjustment is needed; be aware of the theoretical effect on filgotinib response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Filgotinib
- Carvedilol + Filgotinib Minor
- Diltiazem + Filgotinib Minor
- Filgotinib + Simvastatin Minor
Other interactions of Fenofibrate
- Atorvastatin + Fenofibrate Moderate
- Cholestyramine + Fenofibrate Moderate
- Cholic acid + Fenofibrate Moderate
- Colchicine + Fenofibrate Moderate
- Colestipol + Fenofibrate Moderate
- Cyclosporine + Fenofibrate Moderate
Frequently asked questions
Can I take Fenofibrate with Filgotinib?
MediHelp rates the interaction as minor. Fenofibrate and Filgotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fenofibrate inhibits CES2 in vitro, and CES2 converts filgotinib to its active metabolite. The clinical relevance is unknown and no meaningful effect has been demonstrated.
How serious is the interaction between Fenofibrate and Filgotinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; be aware of the theoretical effect on filgotinib response.
What other medicines interact with Filgotinib?
MediHelp also lists interactions of Filgotinib with, for example, Carvedilol, Diltiazem, Simvastatin. The full list is on the Filgotinib page.
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