Drug interactions
Diltiazem + Fludrocortisone
Severity: Minor
Diltiazem and Fludrocortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem may modestly increase fludrocortisone exposure, potentially enhancing mineralocorticoid effects such as fluid retention, hypokalemia and raised blood pressure.
What this interaction means in plain words
Diltiazem and Fludrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diltiazem belongs to Cardiovascular; Fludrocortisone belongs to Endocrine.
Why it happens
Diltiazem inhibits CYP3A4 metabolism of fludrocortisone.
What to do
Monitor blood pressure, edema and serum potassium, and adjust the fludrocortisone dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Diltiazem with Fludrocortisone?
MediHelp rates the interaction as minor. Diltiazem and Fludrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Diltiazem may modestly increase fludrocortisone exposure, potentially enhancing mineralocorticoid effects such as fluid retention, hypokalemia and raised blood pressure.
How serious is the interaction between Diltiazem and Fludrocortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, edema and serum potassium, and adjust the fludrocortisone dose if needed.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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