Drug interactions
Diltiazem + Glipizide-metformin
Severity: Minor
Diltiazem and Glipizide-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium channel blockers can mildly worsen glucose tolerance and may reduce the effect of antidiabetic drugs. Diltiazem may also modestly raise metformin exposure via transporter effects.
What this interaction means in plain words
Diltiazem and Glipizide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diltiazem belongs to Cardiovascular; Glipizide-metformin belongs to Endocrine.
Why it happens
Calcium channel blockade may reduce insulin secretion and diltiazem may inhibit renal transporters.
What to do
Monitor blood glucose when diltiazem is started or stopped and adjust therapy only if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glipizide-metformin
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Diltiazem with Glipizide-metformin?
MediHelp rates the interaction as minor. Diltiazem and Glipizide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium channel blockers can mildly worsen glucose tolerance and may reduce the effect of antidiabetic drugs. Diltiazem may also modestly raise metformin exposure via transporter effects.
How serious is the interaction between Diltiazem and Glipizide-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when diltiazem is started or stopped and adjust therapy only if control changes.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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