Drug interactions
Diltiazem + Glyburide-metformin
Severity: Minor
Diltiazem and Glyburide-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium channel blockers like diltiazem can modestly worsen glucose control in some diabetic patients. Diltiazem may also increase glyburide exposure through CYP3A4 inhibition, so the effects on glucose can go in either direction.
What this interaction means in plain words
Diltiazem and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diltiazem belongs to Cardiovascular; Glyburide-metformin belongs to Endocrine.
Why it happens
Calcium channel blockade may reduce insulin secretion, while CYP3A4 inhibition may raise glyburide levels.
What to do
Monitor blood glucose when diltiazem is started or stopped and adjust antidiabetic doses as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Diltiazem with Glyburide-metformin?
MediHelp rates the interaction as minor. Diltiazem and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium channel blockers like diltiazem can modestly worsen glucose control in some diabetic patients. Diltiazem may also increase glyburide exposure through CYP3A4 inhibition, so the effects on glucose can go in either direction.
How serious is the interaction between Diltiazem and Glyburide-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when diltiazem is started or stopped and adjust antidiabetic doses as needed.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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